Evaluation of Carotid Artery Doppler & Its Correlation with Non-Contrast Computed Tomography Head in Ischemic Stroke Patients
DOI:
https://doi.org/10.71393/encz1k30Keywords:
Ischemic stroke; Carotid Doppler; Carotid stenosis; NCCT head; ASPECTSAbstract
Introduction: Ischemic stroke is a major cause of mortality and long-term neurological disability. Carotid atherosclerosis is an important and potentially treatable contributor, while non-contrast computed tomography (NCCT) demonstrates cerebral ischemic injury. Combined assessment may improve etiological evaluation, vascular characterization, and risk stratification in affected patients.
Aim & Objective: The study aimed to assess the correlation between carotid artery Doppler and non-contrast CT findings in ischemic stroke, identify commonly involved vascular territories, and evaluate major risk factors for carotid artery stenosis.
Materials & Methods: This prospective study was conducted in the Department of Radiodiagnosis, G.R. Medical College, Gwalior, Madhya Pradesh, among 96 clinically suspected stroke patients with ischemic stroke on CT. Patients with head injury, space-occupying lesions, demyelinating disorders, stroke mimics, or refusal of consent were excluded. Carotid Doppler parameters, plaque characteristics, stenosis severity, vascular territories, and NCCT findings were analyzed and correlated statistically.
Results: Mean age was 60.91 ± 8.32 years; 56.3% were males. Carotid stenosis was detected in 74.0%, most commonly <50% stenosis (47.9%), while complete occlusion occurred in 2.1%. Echogenic plaque was most frequent (34.38%). Right and left ICA peak systolic velocities and bilateral ICA/CCA ratios were significantly higher in stenosis. MCA territory predominated, with right MCA infarction in 22.9% and left MCA in 20.8%. Hypertension, diabetes, smoking, and hyperlipidemia were significantly associated with stenosis. ASPECTS correlated inversely with stenosis percentage (r=-0.764) and ICA Doppler parameters.
Conclusion: Carotid Doppler and NCCT are complementary modalities for evaluating ischemic stroke. Increasing carotid stenosis is associated with greater cerebral ischemic burden, supporting combined imaging for diagnosis, vascular risk assessment, risk stratification, clinical management and secondary prevention.
REFERENCES
- Singh RJ, Chen S, Ganesh A, Hill MD. Long-term neurological, vascular, and mortality outcomes after stroke. Int J Stroke. 2018;13(8):787-796. https://doi.org/10.1177/1747493018798526
- Feigin VL, Owolabi MO, Abd-Allah F, Akinyemi RO, Bhattacharjee NV, Brainin M, et al. Pragmatic solutions to reduce the global burden of stroke: a World Stroke Organization-Lancet Neurology Commission. Lancet Neurol. 2023;22(12):1160-1206. https://doi.org/10.1159/000535377
- Hou S, Zhang Y, Xia Y, Liu Y, Deng X, Wang W, et al. Global, regional, and national epidemiology of ischemic stroke from 1990 to 2021. Eur J Neurol. 2024;31(12):1-14.
- Campbell BC, De Silva DA, Macleod MR, Coutts SB, Schwamm LH, Davis SM, et al. Ischaemic stroke. Nat Rev Dis Primers. 2019;5(1):1-11. https://doi.org/10.1038/s41572-019-0118-8
- Maida CD, Norrito RL, Daidone M, Tuttolomondo A, Pinto A. Neuroinflammatory mechanisms in ischemic stroke: focus on cardioembolic stroke, background, and therapeutic approaches. Int J Mol Sci. 2020;21(18):1-33. https://doi.org/10.3390/ijms21186454
- Kleindorfer DO, Towfighi A, Chaturvedi S, Cockroft KM, Gutierrez J, Lombardi-Hill D, et al. 2021 guideline for the prevention of stroke in patients with stroke and transient ischemic attack: a guideline from the American Heart Association/American Stroke Association. Stroke. 2021;52(7):364-467. https://doi.org/10.1161/str.0000000000000375
- Costanzo L, Failla G, Aluigi L, Baroncelli TA, Bua C, De Marchi S, et al. Operative procedures for ultrasound assessment of extracranial artery disease: a narrative review by the Italian Society for Vascular Investigation (SIDV). J Clin Med. 2025;14(19):1-47. https://doi.org/10.3390/jcm14197050
- Polak JF, Alexandrov AV. Accuracy of the Society of Radiologists in Ultrasound (SRU) carotid Doppler velocity criteria for grading North American Symptomatic Carotid Endarterectomy Trial (NASCET) stenosis: a meta-analysis. J Ultrasound Med. 2023;42(7):1423-1435. https://doi.org/10.1002/jum.16150
- Karn AK, Narayan S, Qavi A, Maurya PKK, Singh A, Kulshreshtha D. Sequential carotid Doppler study in acute stroke and its clinical correlation: a prospective study. J Neurosci Rural Pract. 2024;15(1):42-46. https://doi.org/10.25259/jnrp_342_2023
- De La Paz R, Wippold F, Cornelius R. American College of Radiology ACR Appropriateness Criteria: cerebrovascular disease. Reston (VA): American College of Radiology; 2012:1-23. https://doi.org/10.1016/j.jacr.2009.02.008
- Abdalkader M, Siegler JE, Lee JS, Yaghi S, Qiu Z, Huo X, et al. Neuroimaging of acute ischemic stroke: multimodal imaging approach for acute endovascular therapy. J Stroke. 2023;25(1):55-71. https://doi.org/10.5853/jos.2022.03286
- Nowinski WL, Walecki J, Półtorak-Szymczak G, Sklinda K, Mruk B. Ischemic infarct detection, localization, and segmentation in noncontrast CT human brain scans: review of automated methods. PeerJ. 2020;8:1-26. https://doi.org/10.7717/peerj.10444
- Haq S, Mathur M, Singh J, Kaur N, Sibia RS, Badhan R. Colour Doppler evaluation of extracranial carotid artery in patients presenting with acute ischemic stroke and correlation with various risk factors. J Clin Diagn Res. 2017;11(3):1-4. https://doi.org/10.7860/jcdr/2017/25493.9541
- Reddy RH, Diggikar P, Mundada M, Oommen A, Pancholi T, Yammanuru B, et al. A comprehensive study of risk factors, etiology, and infarction patterns in cerebrovascular accidents at a tertiary care hospital in India. Cureus. 2024;16(9):1-10. https://doi.org/10.7759/cureus.68433
- Raghuwanshi SK, Kadwey S, Kaushal L. Correlation of carotid Doppler with non-contrast computed tomography head and magnetic resonance imaging brain in patients of acute cerebral ischemia. Int J Sci Stud. 2021;9(1):69-76.
- Sehrawat S, Thind SS, Singh V, Kuber R, Naware S, Shrotri H. Colour Doppler evaluation of extracranial carotid artery in patients presenting with features of cerebrovascular disease: a clinical and radiological correlation. Med J Dr DY Patil Vidyapeeth. 2012;5(2):137-143. https://doi.org/10.4103/0975-2870.103344
- Bollipo JP, Rao PB. Color Doppler assessment of extracranial carotid arteries in carotid artery disease with correlation of risk factors in predicting cerebrovascular accident in patients with carotid atheromatous disease. 2018:1402–1406. https://doi.org/10.18203/2349-3933.ijam20184718
- Gaur A, Modi B. Colour Doppler evaluation of carotid arteries in ischemic stroke patients. Int J Sci Res. 2022:41-44. https://doi.org/10.36106/ijsr/2401385
- Ahmed L, Noori FA. Carotid Doppler study in patients with cerebral infarction. J Fac Med Baghdad. 2011;53(4):363-366.
- Pisimisis GT, Katsavelis D, Mandviwala T, Barshes NR, Kougias P. Common carotid artery peak systolic velocity ratio predicts high-grade common carotid stenosis. J Vasc Surg. 2015;62(4):951-957. https://doi.org/10.1016/j.jvs.2015.05.009
- Garg S, Kashikar SV, Phatak S. Colour Doppler evaluation of extracranial carotid arteries: a clinical and radiological correlation. J Clin Diagn Res. 2016;10(1):6-9. https://doi.org/10.7860/jcdr/2016/15426.7130
- Su TC, Jeng JS, Chien KL, Sung FC, Hsu HC, Lee YT. Hypertension status is the major determinant of carotid atherosclerosis: a community-based study in Taiwan. Stroke. 2001;32(10):2265-2271. https://doi.org/10.1161/str.32.10.2265
